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KMID : 1141520180330030364
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Endocrinology and Metabolism
2018 Volume.33 No. 3 p.364 ~ p.371
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Calpain-10 and Adiponectin Gene Polymorphisms in Korean Type 2 Diabetes Patients
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Nam Ji-Sun
Han Jung-Woo
Lee Sang-Bae
You Ji-Hong
Kim Min-Jin
Kang Shin-Ae
Park Jong-Suk
Ahn Chul-Woo
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Abstract
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Background: Genetic variations in calpain-10 and adiponectin gene are known to influence insulin secretion and resistance in type 2 diabetes mellitus. Recently, several single nucleotide polymorphisms (SNPs) in calpain-10 and adiponectin gene have been reported to be associated with type 2 diabetes and various metabolic derangements. We investigated the associations between specific calpain-10 and adiponectin gene polymorphisms and Korean type 2 diabetes patients.
Methods: Overall, 249 type 2 diabetes patients and 131 non-diabetic control subjects were enrolled in this study. All the subjects were genotyped for SNP-43 and -63 of calpain-10 gene and G276T and T45G frequencies of the adiponectin gene. The clinical characteristics and measure of glucose metabolism were compared within these genotypes.
Results: Among calpain-10 polymorphisms, SNP-63 T/T were more frequent in diabetes patients, and single SNP-63 increases the susceptibility to type 2 diabetes. However, SNP-43 in calpain-10 and T45G and intron G276T in adiponectin gene were not significantly associated with diabetes, insulin resistance, nor insulin secretion.
Conclusion: Variations in calpain-10, SNP-63 seems to increase the susceptibility to type 2 diabetes in Koreans while SNP-43 and adiponectin SNP-45, -276 are not associated with impaired glucose metabolism.
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KEYWORD
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Calpain 10, Adiponectin, Diabetes mellitus, type 2
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